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The CDRS-R is a commonly used clinician-rated instrument that covers 17 symptom areas of depression relevant to adolescents, including impaired schoolwork, difficulty having fun, social withdrawal, physical complaints, and low self-esteem. An earlier open-label trial showed a 78 percent success rate with antidepressants known as selective serotonin reuptake inhibitors SSRIs. For some, the drug was active on serotonin and probably was effective, and for others, it was a placebo effect. A double-blind, parallel-group, placebo-controlled phase III study to evaluate the safety and efficacy of Lexapro in the treatment of depressed adolescents, aged 12-17, was conducted in multiple centers across the US A total of 316 patients entered the eight week study, receiving either Lexapro 10-20 mg n15 or placebo n15. The trial also showed that Lexapro was generally well-tolerated some, catalyzed lexapro symptom withdrawal.
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